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Insulin resistance, the progression of liver disease, and living

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the com breathing disorder, regardless of people's weight, according to reports published in the February issue of the American Journal of Respiratory and Critical Care Medicine. Keefer Bradley, professor of medicine and director of
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the Centre for
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Sleep Medicine and Circadian Biology at the University of Toronto, explained in the news release. The researchers found these changes in people who were sedentary but not
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obese and who they suspected had obstructive sleep apnea -- a discovery that might help explain why 40 percent of people with the breathing disorder are not obese and why exercise without weight loss appears to reduce sleep
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apnea issues in some people. Naresh Punjabi, an associate professor of medicine and epidemiology at Johns Hopkins University School of Medicine, said in an American Thoracic Society news release.
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"The hypoxic stress of OSA may induce oxidative stress in the livers of patients with severe obesity, leading to further inflammation." Enzyme levels and other findings, though, suggest that obesity and sleep apnea are not completely tied
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Sleep -- Three conditions often linked to obesity have also been tied independently to sleep apnea, new studies show. "Our data suggest that patients with OSA and severe nocturnal
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hypoxemia should be screened for liver disease, and, conversely, patients with liver disease should be screened for OSA," Polotsky said.

"We hypothesize that severe obesity, per se, acts as a first hit in the progression of

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liver disease, inducing hepatic steatosis, whereas the presence
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of the chronic intermittent hypoxemia that often characterizes OSA acts as a second hit," lead researcher Dr. "An important implication of our
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observations is that sedentary living may predispose to OSA, not only by promoting obesity but also by causing dependent fluid accumulation in the legs, which can shift rostrally to the neck overnight," Svend said. A Walt Hopkins University study found a strong tie between insulin resistance -- the body's inability to metabolize glucose -- and sleep-disordered breathing (SDB), pauses or
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other abnormalities in breathing while sleeping. Polotsky, of the Johns Hopkins
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Asthma and Allergy Center, said in the same news release. When people lie down to sleep, fluid that has been retained in the legs during the day gets redistributed to the upper body, Dr. "What our research tells us is that
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type 2 diabetes mellitus," study leader Dr.

Another Hopkins study found that obese people with chronic intermittent hypoxia, the lack of oxygen that occurs during obstructive sleep apnea (OSA), sho liver issues in proportion to the severity

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of the sleep disorder. The third study found that excessive sitting or standing during the day causes a fluid shift in the legs during sleep that may have a role in the development of sleep apnea. "It is, therefore, plausible that some of the displaced fluid might reach the neck and predispose one to upper airway constriction," he said. The National Heart, Lung and Blood Institute has more about sleep apnea..







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